![]() Do not take Atorvastatin with grapefruit juice. Food and Chemical Toxicology 1993 (31)5:331-5. Notes for Consumers: Side effects from Atorvastatin may get worse if you drink grapefruit juice. Includes information on severity of interaction and the level of evidence for it. ![]() See the list of drugs that interact with Grapefruit. Journal of Food and Drug Analysis 2017 (25) 1:71-83. Grapefruit juice is predicted to increase the exposure to Zanubrutinib. Additionally, grapefruit juice might interfere with the bioavailability of statins that are substrates of organic anion transporting polypeptides (OATP). Chemistry and health effects of furanocoumarins in grapefruit. Grapefruit juice can increase blood levels of statins that are metabolized by cytochrome P450 3A4 (CYP3A4), potentially increasing the effects and adverse effects of these statins. Grapefruit juice and any grapefruit products should be avoided, as should large quantities of limes or lime peel, although small amounts (such as a twist of lime in a drink) are unlikely to cause a significant interaction. Out of all the statins, atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Altoprev) have the strongest interaction with grapefruit, and this is likely to be true for other citrus. Atorvastatin interacts with grapefruit juice if you drink large quantities (more than 1.2 litres daily), but. Unfortunately, in humans, furanocoumarins block one of the main liver enzymes involved in the metabolism of some statins, called CYP3A4, which could lead to increased blood levels of the interacting drug, leading to more severe side effects, including muscle pain. Statins are medicines that lower your cholesterol. Why Grapefruit and Some Statins Don’t Mix: Interactions and Side Effects Explained Written by Austin Ulrich, PharmD, BCACP. However, it can interact with rosuvastatin. Limes, lemons, and bergamot also contain bergamottin, with limes reported to contain the highest amount, especially peel. Niacin (Niacor) is a B vitamin also known as vitamin B3 that’s sometimes taken to help lower cholesterol. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260 if taken at the same time (about 90 if taken 12 hours apart), and atorvastatin by about 80 (whenever taken). Research has previously identified bergamottin as the main statin-interacting substance in grapefruit. The major furanocoumarins found in grapefruit include bergamottin, epoxybergamottin, and 6′,7′-dihydroxybergamottin. Rather, grapefruit seems to boost statins’ power to act on the body, while also potentially boosting its side effects. Grapefruit juice changes the way this drug breaks. And if you take pravastatin, rosuvastatin, fluvastatin, or pitavastatin. Concomitant intake of large quantities of grapefruit juice and atorvastatin is not recommended. This is not the case with grapefruit and statins. Calcium channel blockers are prescribed for high blood pressure and are also affected by grapefruit juice. CBD competes with atorvastatin for metabolism through this enzyme. CBD and atorvastatin are both metabolized in the liver by the same enzyme (CYP3A4). So he doesn’t advise people on statins to avoid grapefruit juice. Interaction 1: Slowed Elimination (Metabolic competition) The main interaction between CBD and atorvastatin takes place in the liver. Grapefruit, limes, and other citrus fruits contain furanocoumarins, which are compounds that help protect the fruit from certain insects and infections. Greenfield says that although there is a well-defined interaction between grapefruit juice and certain statins, this interaction actually results in a further reduction of bad LDL cholesterol. Often-prescribed medicines that can interact with grapefruit include medicines that: Fight infection. There just hasn't been as much research published regarding how other types of citrus (apart from grapefruit) interact with statins. ![]() Keep in mind that each category contains several other medications that aren't affected by grapefruit.Limes, pomegranates, pomelos, and Seville oranges can also interact with some medications, including statins such as atorvastatin. Grapefruit juice has a chemical that can interfere with the enzymes that break down the statins in your digestive system. Grapefruit and grapefruit juice can boost blood levels of various prescription medications. common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin. Some of the most common drugs affected by grapefruit are listed below. ![]() The potency of some cardiovascular and other drugs is affected by grapefruit, pomelo, and other juices.
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